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Researchers have designed a nanoparticle-based therapy that is effective in treating mice with multiple myeloma, a cancer of bone marrow immune cells. Targeted specifically to the malignant cells, these nanoparticles protect their therapeutic cargo from degradation in the bloodstream and greatly enhance drug delivery into the cancer cells.

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Studying West Nile virus infection in mice, scientists at Washington University School of Medicine in St. Louis have shown that an antiviral compound tightens the blood-brain barrier, making it harder for the virus to invade the brain.

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A diabetes drug may have benefits beyond lower blood sugar in patients with HIV. New research from the laboratory of Kevin E. Yarasheski, PhD, suggests the drug may prevent cardiovascular problems because it works to reduce inflammation that is linked to heart disease and stroke in these patients. The drug both improved metabolism and reduced inflammation in HIV-positive adults on antiretroviral therapy.

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A newly discovered link between bacteria and immune cells sheds light on inflammatory bowel disease, an autoimmune condition that affects 1.6 million people in the United States, according to researchers at Washington University School of Medicine in St. Louis.

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Transgender and non-transgender lesbian, gay and bisexual students are at greater risk for eating disorders, finds a new study from the Brown School and Washington University School of Medicine in St. Louis. The study used data from 289,024 students at 223 U.S. universities participating in the American College Health Association–National College Health Assessment. Alexis Duncan, PhD, assistant professor at the Brown School, was senior author on the study.
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Researchers led by John F. DiPersio, MD, PhD, at the School of Medicine have designed a way to mitigate graft-versus-host disease, a common and often life-threatening complication of bone marrow transplants that are used to treat leukemia and other blood cancers. The method also employs a molecular imaging tool to help doctors identify patients most likely to develop this dangerous condition.

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The Washington University AIDS Clinical Trials Unit is the first in the nation to open a clinical trial evaluating whether statins reduce heart attacks and strokes in patients with human immunodeficiency virus (HIV). MORE
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Joni Westerhouse
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(314) 286-0120
westerhousej@wustl.edu