Clark's career is distinguished by a wide-ranging involvement in both traditional and non-traditional branches of theoretical physics. For three decades he has played a leading role in the development of methods for quantitative prediction of the properties of strongly interacting quantum many-particle systems such as atomic nuclei, neutron stars, and Bose-Einstein condensates.

Since the mid-1970s, Clark's research has been increasingly cross-disciplinary in character. Currently his research interests are nucleonic superfluidity in neutron stars, broken symmetries in liquid helium, short-range correlations in electron-nucleus scattering, database mining in nuclear physics, and quantum control theory. Working with faculty in the Washington University School of Medicine, he is engaged in theoretical research in neural information processing and computational neuroscience.

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